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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SOCS3
All Species:
20.3
Human Site:
S203
Identified Species:
40.61
UniProt:
O14543
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O14543
NP_003946.3
225
24770
S203
T
V
N
G
H
L
D
S
Y
E
K
V
T
Q
L
Chimpanzee
Pan troglodytes
XP_509267
198
22155
A177
T
I
N
K
C
T
G
A
I
W
G
L
P
L
P
Rhesus Macaque
Macaca mulatta
XP_001106015
576
62574
S554
T
V
N
G
H
L
D
S
Y
E
K
V
T
Q
L
Dog
Lupus familis
XP_848851
225
24779
S203
T
V
N
G
H
L
D
S
Y
E
K
V
T
Q
L
Cat
Felis silvestris
Mouse
Mus musculus
O35718
225
24758
S203
T
V
N
G
H
L
D
S
Y
E
K
V
T
Q
L
Rat
Rattus norvegicus
O88583
225
24790
S203
T
V
N
G
H
L
D
S
Y
E
K
V
T
Q
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516256
214
23730
Y193
V
N
G
H
L
E
S
Y
E
K
V
A
Q
L
P
Chicken
Gallus gallus
Q90X67
209
23158
Y188
V
N
G
H
L
D
S
Y
E
K
M
T
Q
L
P
Frog
Xenopus laevis
P13116
532
59718
R476
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
Zebra Danio
Brachydanio rerio
NP_998469
210
23421
S189
L
N
G
H
I
D
V
S
T
K
R
D
Q
L
P
Tiger Blowfish
Takifugu rubipres
NP_001072096
201
22742
S180
V
N
G
L
V
D
V
S
S
R
R
D
Q
L
P
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_799032
227
25956
P204
T
V
N
K
T
V
E
P
R
Y
V
N
D
L
C
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
28
38.5
97.7
N.A.
96.8
95.5
N.A.
79.5
84
20.1
61.3
57.3
N.A.
N.A.
N.A.
35.2
Protein Similarity:
100
45.3
38.8
99.1
N.A.
97.3
96.4
N.A.
86.2
88.4
28.2
74.6
70.6
N.A.
N.A.
N.A.
52.4
P-Site Identity:
100
13.3
100
100
N.A.
100
100
N.A.
0
0
6.6
6.6
6.6
N.A.
N.A.
N.A.
20
P-Site Similarity:
100
33.3
100
100
N.A.
100
100
N.A.
6.6
6.6
33.3
20
13.3
N.A.
N.A.
N.A.
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
9
0
0
0
9
0
0
0
% A
% Cys:
0
0
0
0
9
0
0
0
0
0
0
0
0
9
9
% C
% Asp:
0
0
0
9
0
25
42
0
0
0
0
17
9
0
0
% D
% Glu:
9
0
0
0
0
9
17
0
17
42
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
34
42
0
0
9
0
9
0
9
0
0
0
0
% G
% His:
0
0
0
25
42
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
9
0
0
9
0
0
0
9
0
0
0
0
0
0
% I
% Lys:
0
0
0
17
0
0
0
0
0
25
42
0
0
0
0
% K
% Leu:
9
0
9
9
17
42
0
0
0
0
0
9
0
50
42
% L
% Met:
0
0
0
0
0
0
0
0
0
0
9
9
0
0
0
% M
% Asn:
0
34
59
0
0
0
0
0
0
0
0
9
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
9
0
0
0
0
17
0
50
% P
% Gln:
0
0
0
0
9
0
0
0
0
0
0
0
34
42
0
% Q
% Arg:
0
0
0
0
0
0
0
9
9
9
25
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
17
59
9
0
0
0
0
0
0
% S
% Thr:
59
0
0
0
9
9
0
0
9
0
0
9
42
0
0
% T
% Val:
25
59
0
0
9
17
17
0
0
0
17
42
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
9
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
17
42
17
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _